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Consists of 2 types; primary and secondary Primary adrenal insufficiency is also called Addison's disease ETIOLOGY Primary - Autoimmune (most common) - Hemorrhage; trauma, illness, pregnancy - Infections; HIV, CMV, TB - Amyloidosis and Hemochromatosis - Congenital - Drugs; ketoconazole, etomidate, mitotane Secondary - Iatrogenic CLINICAL FEATURES - Weakness, Fatigue - Weight loss - Nausea, Vomiting, Diarrhea, Abdominal pain - Orthostatic hypotension - Coma, Death - Hyper pigmentation of oral mucosa and palmar creases DIAGNOSIS - Blood work; BMP (hyponatremia, hyperkalemia) - Cortisol test - Cosyntropin stimulation test TREATMENT - Fludrocortisone, Hydrocortisone, Prednisone

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