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Herpes Zoster is the reactivation of varicella zoster virus infection. It usually presents as a painful vesicular eruption with a dermatomal distribution. PATHOPHYSIOLOGY The varicella virus lives inactive in the dorsal root / cranial nerve ganglia after primary infection. Reactivation of this virus causes replication of the virus in the neuronal bodies and are then carried along the axons to the skin dermatomes, causing the inflammatory eruptions. RISK FACTORS 1. Age (mostly seen in geriatric population) 2. Immunosuppressed state (pregnancy, HIV, malignancy) 3. Spinal surgery 4. Stress 5. ...

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Cluster headaches are more common in middle aged men, with a ratio of 2:1 In women, it is usually seen earlier in life (in their 20s) ASSOCIATED WITH 1. Depression 2. Asthma 3. History of migraines 4. Sleep apnea CLINICAL PRESENTATION The diagnosis is clinical 1. Unilateral, recurrent periorbital pain that lasts from 15 min upto 3 hours 2. Usually at night time 3. Ipsilateral injection, lacrimation and nasal congestion 4. Neurological exam is normal PATHOPHYSIOLOGY Posterior hypothalamus activation > increased parasympathetic outflow The lacrimation, redness and congestion is due to parasympathetic hyperactivity The ptosis and ...

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